Evaluation of Nervous System Disease Models:
- Parkinson's Disease Model: Animals treated with MPTP or 6-OHDA show decreased motor coordination and shortened latency.
- Stroke Model: After middle cerebral artery occlusion (MCAO), contralateral limb function is impaired and latency is shortened.
Pharmacodynamic Evaluation:
- Testing Anti-Parkinsonian Drugs: For example, after administering levodopa, observe whether the rotarod performance of PD model mice is improved.
- Testing Side Effects of Sedatives: For example, sedative drugs can significantly shorten latency.
- Testing the Improvement Effect of New Drugs on Motor Function.
