The Circadian Rhythm Disruption Model is a common method used to study sleep disorders, shift work, and their health impacts. Its core principle is to disrupt the inherent circadian rhythm of mice by altering the light-dark cycle.
By reversing the light-dark cycle, mice are forced to stay awake and active during their inherent sleep period, while attempting to sleep during their inherent active period. This simulates circadian rhythm disruption in humans and enables the study of the resulting physiological and pathological changes.
